Accession Number:

ADA275299

Title:

The Influence of Multiple Host Contacts on the Acquisition and Transmission of Dengue-2 Virus

Descriptive Note:

Doctoral thesis

Corporate Author:

AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s):

Report Date:

1993-01-01

Pagination or Media Count:

106.0

Abstract:

I tested assumptions of the hypothesis that multiple host contacts by Ae. aegypti contribute to dengue virus transmission, the hypothesis assumes multiple meals that combine a viremic meal with a meal from an immune host will not interfere with mosquito infection. I administered enemas, which simulated a second meal from an immune host, to Ae. aegypti that had fed 24 hours earlier from a drop of dengue-2 virus infected blood. Infection rates of the mosquitoes receiving immune sera 85 were significantly lower than the controls 92. Lower infection rates reduce the potential for virus transmission. In vitro transmission rates of the mosquitoes that become infected were not altered by the immune sera.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE