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A Hypereosinophilic Syndrome Associated with HIV Infection
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
Pagination or Media Count:
A hypereosinophilic syndrome associated with dermatitis has been observed rarely in association with HIV infection. We report the case of a young man with AIDS who presented with a diffuse cutaneous eruption, fever, angioedema, eosinophilia and a mildly elevated serum IgE. No allergic or infectious cause of this illness could be determined and the patient was treated with corticosteroids and PUVA therapy with complete resolution of the dermatitis and associated findings. The case exhibited clinical and histopathologic similarities to the idiopathic hypereosinophilic syndrome as well as acute graft-versus-host disease. A serum determination of the cytokine, IL-5, which is associated with eosinophil production, was found to be mildly elevated during the peak of the eruption while samples drawn previously and subsequently were not. A brief review of the literature concerning eosinophils and HIV infection is presented in the context of the present case.
APPROVED FOR PUBLIC RELEASE