Accession Number:

ADA273248

Title:

The 3D Structure of Staphylococcal Enterotoxins

Descriptive Note:

Annual rept. 1 May-30 Sep 1993

Corporate Author:

VETERANS ADMINISTRATION MEDICAL CENTER PITTSBURGH PA

Personal Author(s):

Report Date:

1993-10-15

Pagination or Media Count:

8.0

Abstract:

The overall objective is to determine the crystal structures of the staphylococcal enterotoxins. The 3D structure of SEB has been determined and functional sites on the molecule have been identified. Efforts are underway currently to purify and to crystallize other members of the family, particularly SEA and SEB. The mode of binding of the latter two to MHC class II molecules differs from that of SEB, and this implies a difference in 3D structure could be a likely possibility, although the overall main chain fold of the entire family is expected to be the same. Refinements are in progress on a mitant of SEB and on another polymorph of SEB. Staphylococcal enterotoxins, 3D structures, X-ray diffraction, Protein crystallography, Superantigen, Toxins, Enterotoxins, BD, BL2, RAD IV

Subject Categories:

  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE