Accession Number:

ADA272694

Title:

Acute Toxicity of Quadricyclane

Descriptive Note:

Final rept. May-Nov 92,

Corporate Author:

MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH

Report Date:

1993-01-01

Pagination or Media Count:

16.0

Abstract:

The Air Force is currently developing high energy density matter IIEDM for use as advanced rocket propellants. One group of compounds considered are the strained-ring hydrocarbons. These compounds will be mixed with kerosene to increase the propellants performance. A compound of immediate interest is quadricyclane tetracycloheptane. Quadricyclane C71110 is a colorless, flammable liquid with a boiling point of 180 deg C. Although quadricyclane is available commercially, no acute toxicity information is available in the literature. The Air Force is in the process of screening various propellant candidates in order to select the most promising for further development. Toxicological hazard will be an important criterion for screening candidate compounds. Quadricyclane produced 100 mortality in male Fischer 344 rats within 24 h following gavage at 3.5 gkg. Gavage treatment with a quadricyclanekerosene mixture 70 quadricyclane, 30 kerosene, similar to the proposed rocket fuel mixture, produced toxic effects at a dose level below the EPA limit test. No treatment-related deaths occurred in rabbits following a 24-h dermal exposure to the EPA limit dose of 2 g test materialkg body weight. Dermal exposure, Oral gavage, Quadricyclane, Strained-ring hydrocarbons

Subject Categories:

  • Toxicology
  • Organic Chemistry
  • Fuels
  • Rocket Propellants

Distribution Statement:

APPROVED FOR PUBLIC RELEASE