Campylobacter Immunity and Quantitative Excretion Rates in Thai Children
VETERANS ADMINISTRATION MEDICAL CENTER NASHVILLE TN
Pagination or Media Count:
Campylobacter species were isolated from 61 15 of 416 Thai children 5 years old with diarrhea. Although the baseline levels of Campylobacter-specific antibody increased with age, 80.3 of Campylobacter- infected children seroconverted compared with 12.9 of 45 Shigella-infected patients used as controls. The response to acute infection was greatest in the 6- to 12-month-old group. Nonseroconverters had higher initial IgG levels than did seroconvertersP.001. Quantitative cultures showed a range of 1-8 log sub 10 Campylobacter cfug of stool median, 6.0 log sub 10, and the seroconversion rate was highest in those with the highest Campylobacter excretion. Fecal Campylobacter excretion was inversely related to age x2 for trend, P.03. These studies indicate that endemic Campylobacter exposure frequently induces seroconversion in young children, whether Campylobacter is isolated as a single pathogen or one of multiple pathogens, and that fecal excretion of the organism is inversely related to the age-related immune response to infection.
- Medicine and Medical Research