Extrathalamic Modulation of Cortical Function
Final technical rept. 1 Jul 1990-30 Jun 1993
CALIFORNIA UNIV SAN DIEGO LA JOLLA DEPT OF PSYCHIATRY
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The overall goal of the proposed studies is to characterize the effects of noradrenergic NA afferents on cortical information processing. Our previous studies indicate that the primate locus coeruleus LC system, originating in the pontine brainstem, innervates neocortex more densely than previously thought, exhibiting highly specific patterns in terms of the regional and laminar distribution of its axons across the neocortex. Previous neurophysiological observations suggest that this highly divergent system imposes state-related modulatory effects on thalamo-cortical and cortico- cortical systems. For example, we have shown that primate LC-NA neurons are more active during waking than sleep and exhibit bursts of activity during increases in attentiveness. We have also previously demonstrated that the microiontophoretic application of NA to monkey auditory cortex neurons increases the selectiveness of their responses to auditory stimuli.