Accession Number:

ADA270802

Title:

Interleukin-2 Signal Transduction: A Diffusion-Kinetics Model

Descriptive Note:

Corporate Author:

NAVAL ACADEMY ANNAPOLIS MD

Personal Author(s):

Report Date:

1993-05-17

Pagination or Media Count:

95.0

Abstract:

The diffusion-kinetics model for the interactions between interleukin-2 and each of its T-cell surface receptors IL-2 alpha and IL-2 beta is presented. This model is unique in that it considers both three dimensional ligand-receptor interactions and two dimensional interactions between cell surface-bound species. Elementary rate laws are developed for initial encounters, rebounding interactions, and dissociations of free ligands and receptors according to the method of Waite and Waite and Stewart. Analogous rate laws are written for membrane bound species which undergo similar initial associations, rebounding interactions, and dissociations. A set of kinetic equations is proposed for a system consisting of two independent monovalent receptors and one monovalent ligand, simulating the interaction of the IL-2 alpha and IL-2 beta receptors of the human T-cell with the lymphokine interleukin-2. Autocrine and paracrine growth and combinations of the two are studied by modifying the appropriate experimental parameters. Experimental associative and dissociative rate constants are determined for important T-cell surface species.

Subject Categories:

  • Medicine and Medical Research
  • Mechanics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE