Accession Number:

ADA270793

Title:

The Pharmacology of p-Aminopropiophenone in the Detoxification of Cyanide

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1992-01-01

Pagination or Media Count:

20.0

Abstract:

PAPP is effective as a pretreatment antidote to cyanide when used by single-dose administration. Further experiments need to be performed to establish a lack of toxicity of PAPP in multiple-dose experiments. Possible chronic hematological and genotoxic effects of PAPP may limit its development in repeated chronic treatment. Combination therapy of a prophylactic sulfur donor with a low dose of a safer prophylactic aminophenone e.g., PAOP or p- aminoheptanoylphenone or their N-hydroxy metabolites may provide more efficacious protection against cyanide than PAPP. This combination could allow for a reduction in the dosage of MetHb formers that would reduce the chance of unwanted side effects of the employed therapeutic compounds.

Subject Categories:

  • Anatomy and Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE