Comparative Toxicity of Halogenated Hydrocarbons: Molecular Aspects
Final rept. 1 Jan-31 Dec 1992
SURREY UNIV GUILDFORD (UNITED KINGDOM) MOLECULAR TOXICOLOGY GROUP
Pagination or Media Count:
The comparative hepatotoxicities of perfluorooctanoic acid PFOA, perfluorodecanoic acid PFDA and the tri-and tetra-oligomers of chloro- trifluoro ethylene CTFE have been investigated in the rat and guinea pig. All compounds have been identified as causing hepatomegaly, peroxisome proliferation and cytochrome P4504A1 induction in the rat. The guinea pig is non-responsive to these compounds and the observed liver changes appear to be specific to lower rodent species. The implications of this study are that the above compounds do not represent a health hazard to man.
- Medicine and Medical Research
- Organic Chemistry