Accession Number:

ADA270287

Title:

Comparative Toxicity of Halogenated Hydrocarbons: Molecular Aspects

Descriptive Note:

Final rept. 1 Jan-31 Dec 1992

Corporate Author:

SURREY UNIV GUILDFORD (UNITED KINGDOM) MOLECULAR TOXICOLOGY GROUP

Personal Author(s):

Report Date:

1993-07-13

Pagination or Media Count:

8.0

Abstract:

The comparative hepatotoxicities of perfluorooctanoic acid PFOA, perfluorodecanoic acid PFDA and the tri-and tetra-oligomers of chloro- trifluoro ethylene CTFE have been investigated in the rat and guinea pig. All compounds have been identified as causing hepatomegaly, peroxisome proliferation and cytochrome P4504A1 induction in the rat. The guinea pig is non-responsive to these compounds and the observed liver changes appear to be specific to lower rodent species. The implications of this study are that the above compounds do not represent a health hazard to man.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE