Accession Number:

ADA269769

Title:

Mechanisms of Cytotoxicity of the Aids Virus

Descriptive Note:

Annual rept. 17 Sep 1991-16 Sep 1992

Corporate Author:

WASHINGTON UNIV ST LOUIS MO DIV OF HEMATOLOGY-ONCOLOGY

Personal Author(s):

Report Date:

1992-10-10

Pagination or Media Count:

166.0

Abstract:

Regulatory genes of HIV-1, HIV-2, and SIV are important in modulating virus infection and infection and transmission in vivo. Viral proteins R VPR and X VPX and the negative factor-NEF are three of the least well characterized regulatory proteins. Identification of their functions, their mechanisms of actions, and structure-function relationships of each protein, in vitro and in vivo will assist in our understanding of the pathogenesis of HIV- induced disease. This information will be critical in defining therapeutic approaches to suppression HIV-1 infection, replication, and transmission. VPR, VPX, NEF, HIV-1, VPU, AIDS, Cytotoxicity, Biology, Biotechnology, RAD I

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE