Accession Number:

ADA269725

Title:

Molecular Studies of HTLV-1 Infection in Newly Recognized High Risk Population

Descriptive Note:

Final rept. 16 Oct 1991-9 Jun 1993

Corporate Author:

TEL-AVIV UNIV (ISRAEL)

Personal Author(s):

Report Date:

1993-07-10

Pagination or Media Count:

105.0

Abstract:

The report summarizes the two years of contract of the research aimed to define newly recognized high risk population for HTLV-I infection. To define the extent of HTLV-I infection among groups of Jewish immigrants to Israel with an increased frequency of Adult T-cell Leukemia ATL. Various serological and molecular screening of methods were used, including ELISA and PCR use for molecular survey by amplification of HTLV-I proviral DNA from peripheral blood mononuclear cells DNA. overall rate of infection is 12 for Jews arriving from Khurusan-North-Eastern Iran. No positive HTLV-I carries were found from other parts of Iran, Ethiopia, and other Mid-Eastern countries, We could not identify HTLV-I seropositive patients in Insulin Dependent DiabeteS Mellitus IDDM patients in children with non-Burkitt lymphomas, Psoriasis and Parapsoriasis patients, DNA Sequence data for HTLV-I isolates are provided showing similar sequence to African isolates. HTLV-I, Epidemiology, Polymerase, Virus, Aids, Biotechnology, RAD I.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE