Accession Number:
ADA269725
Title:
Molecular Studies of HTLV-1 Infection in Newly Recognized High Risk Population
Descriptive Note:
Final rept. 16 Oct 1991-9 Jun 1993
Corporate Author:
TEL-AVIV UNIV (ISRAEL)
Personal Author(s):
Report Date:
1993-07-10
Pagination or Media Count:
105.0
Abstract:
The report summarizes the two years of contract of the research aimed to define newly recognized high risk population for HTLV-I infection. To define the extent of HTLV-I infection among groups of Jewish immigrants to Israel with an increased frequency of Adult T-cell Leukemia ATL. Various serological and molecular screening of methods were used, including ELISA and PCR use for molecular survey by amplification of HTLV-I proviral DNA from peripheral blood mononuclear cells DNA. overall rate of infection is 12 for Jews arriving from Khurusan-North-Eastern Iran. No positive HTLV-I carries were found from other parts of Iran, Ethiopia, and other Mid-Eastern countries, We could not identify HTLV-I seropositive patients in Insulin Dependent DiabeteS Mellitus IDDM patients in children with non-Burkitt lymphomas, Psoriasis and Parapsoriasis patients, DNA Sequence data for HTLV-I isolates are provided showing similar sequence to African isolates. HTLV-I, Epidemiology, Polymerase, Virus, Aids, Biotechnology, RAD I.
Descriptors:
- *MOLECULAR BIOLOGY
- *HUMAN IMMUNODEFICIENCY VIRUSES
- *EPIDEMIOLOGY
- *LYMPHOMAS
- *LEUKEMIA
- *ACQUIRED IMMUNE DEFICIENCY SYNDROME
- FREQUENCY
- ISRAEL
- RISK
- MIDDLE EAST
- CELLS
- PATIENTS
- BIOTECHNOLOGY
- AFRICANS
- NUCLEOTIDES
- INSULIN
- CHILDREN
- BLOOD
- DIABETES
- ADULTS
- SEROLOGY
- IRAN
- JEWS
- ETHIOPIA
- VIRUSES
- AMPLIFICATION
- ENZYMES
- RATES
- POPULATION
- SEQUENCES
- SURVEYS
Subject Categories:
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research
- Microbiology