Accession Number:

ADA266059

Title:

Studies of Mechanisms of Pharmacological Enhancement of Functional Recovery After Cortical Contusion

Descriptive Note:

Final rept. 4 Jan 1991-31 Dec 1992

Corporate Author:

NEW MEXICO UNIV ALBUQUERQUE

Personal Author(s):

Report Date:

1993-01-29

Pagination or Media Count:

55.0

Abstract:

Electrophysiology, autoradiography, histochemistry, biochemistry, anatomical, and behavioral research techniques were used in studies to examine remote functional depressions, and the effects of drug treatments on some of these measures, in rats with unilateral ablation of the sensorimotor cortex SMCx or traumatic brain injury contusion TBI centered over the SMCx. In addition to d-amphetamine d-AMPH, drugs increasing norepinephrine NE release were found to accelerate beam-walking BW recovery in rats with SMCx ablation. The dose of d-AMPH required to induce BW recovery after TBI was dependent upon whether the right or left hemisphere was damaged andor the extent of damage to midline cortex. Drugs decreasing NE levels or blocking alphal-NE receptors were found to reinstate BW deficits in rats after SMCx ablation.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE