Accession Number:

ADA265924

Title:

Variations in Time-To-Incapacitation and Blood Cyanide Values for Rats Exposed to Two Hydrogen Cyanide Gas Concentrations

Descriptive Note:

Final rept.

Corporate Author:

FEDERAL AVIATION ADMINISTRATION WASHINGTON DC OFFICE OF AVIATION MEDICINE

Report Date:

1993-05-01

Pagination or Media Count:

19.0

Abstract:

It has been suggested that protective breathing devices protect aircraft passengers from combustion products for 5 min during evacuation and for 35 min during in-flight-plus-evacuation. Hydrogen cyanide HCN, a combustion gas, produces incapacitation at relatively low concentrations, and time-to- incapacitation tiis an applicable index for predicting escape from a fire. Variations in ti and blood cyanide CN value at specific HCN gas exposure concentrations have not been evaluated. Therefore, ti and blood CN value at ti for two HCN concentration that produce 5- and 35- min ti were determined in male Sprague-Dawley rats. Blood CN value levels as a function of HCN exposure time were measured. Animals were individually exposed to HCN gas in a chamber equipped with a rotating cage, and ti recorded as the time from insertion of the animal into the cage until it could no longer walk. At incapacitation and at selected intervals prior to ti, rats were quickly removed from the cage and killed for blood collection and CN value quantitation. Chamber HC concentrations were monitored during the exposures

Subject Categories:

  • Military Aircraft Operations
  • Commercial and General Aviation
  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE