Accession Number:

ADA265839

Title:

Inconclusive Hepatitis C Virus Antibody Results in African Sera

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1993-01-01

Pagination or Media Count:

3.0

Abstract:

In Africa, the prevalence of hepatitis C virus antibody anti-HCV is low compared to the frequency of serologic markers of hepatitis B, but high levels of false-positive anti-HCV ELISA results have been reported. To investigate the causes of false-positive results, sera from 688 outpatients living on the eastern coast of Kenya were evaluated. These data suggest that hepatitis C infection is very infrequent in eastern Kenya however, false- positive ELISA results and inconclusive confirmatory assay results are common but unrelated to flavivirus infection dengue, West Nile and antibody to P. falciparum. False positivity and inconclusive reactions could be related to prolonged storage of samples, cross-reacting antibody to unknown antigens, or infection by HCV variants

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE