The Success of Hepatitis A Vaccine
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Pagination or Media Count:
The report by Lee et al., published in this issue of GASTROENTEROLOGY, gives us necessary information to assess the safety and immunogenicity of the of the SmithKline Beecham hepatitis A vaccine in children. Although the efficacy trials cited above were performed in children, logistical problems did not allow the vigorous clinical and serological monitoring that smaller safety trials permit. The work by lee et al not only fills this information gap but also contributes important facts comparing antibody levels in children who received serum immunoglobulin IG as passive protection against HAV infection. We learn from reading this report that children aged 4-15 years behave immunologically like adults. Moreover, there are no differences in immune response between boys and girls. Minor reactions occurred however, none merits discussion.
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