Accession Number:

ADA265625

Title:

Final Report for Contract N00014-91-J-1815 (University of California, Santa Cruz)

Descriptive Note:

Corporate Author:

CALIFORNIA UNIV SANTA CRUZ

Personal Author(s):

Report Date:

1993-03-10

Pagination or Media Count:

17.0

Abstract:

The goal of this grant was to isolate and characterize the antifouling substances from seaweeds provided by the group at Hopkins Marine Station, Pacific Grove, Calif. Overall, the objectives were accomplished. Zosteric acid was isolated and identified as the key active principle of the alga. A synthesis was developed and the group at Hopkins were trained to carry- out this synthesis work. One staff researcher, visiting professor James Todd was supported by this grant. Two manuscripts were produced from Dr. Todds experimental work. Additional details about these publications is as follows 1 The isolation of a monomeric carboxylic acid of swinholide A from the Indo- Pacific sponge, Theonella swinhoei , James S. Todd, K.A. Alvi, and Phillip Crews, Tetrahedron Letters, Vol. 33, No. 4, pp. 441-442,1992. 2 The antifouling activity of natural and synthesis phenolic acid sulfate esters. James S. Todd, Richard C. Zimmerman, Philip Crews, and Randall S. Alberte, Phytochemistry, in press 1993

Subject Categories:

  • Biochemistry
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE