Accession Number:

ADA265343

Title:

Synergistic Roles of Interleukin-6, Interleukin-1, and Tumor Necrosis Factor in the Adrenocorticotropin Response to Bacterial Lipopolysaccharide in Vivo

Descriptive Note:

Scientific rept.

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Report Date:

1993-01-01

Pagination or Media Count:

9.0

Abstract:

Administration of lipopolysaccharide LPS results in activation of the hypothalamic-pituitary-adrenal axis. LPS induces the release of a number of proinflammatory cytokines, I.E. interleukin-1 IL-1, IL-6, and tumor necrosis factor TNF, which activate the hypothalamic-pituitary-adrenal axis as well and may mediate the effects of LPS. Variations in the kinetics of appearance of IL- 1, TNF, and IL-6 after LPS challenge suggested that these cytokines may play different roles at different times. To elucidate the mutual dependence and contribution of individual cytokines in the course of LPS-induced ACTH release, we used blocking antibodies to IL-6, TNF, and the IL-1 receptor.

Subject Categories:

  • Biochemistry
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE