Accession Number:

ADA265292

Title:

Chromatographic Assessment of Hydrogen-Bond Donating Ability

Descriptive Note:

Technical rept. 1 Jun 92-31 May 93,

Corporate Author:

MINNESOTA UNIV MINNEAPOLIS DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1993-04-22

Pagination or Media Count:

8.0

Abstract:

Generally, hydrogen bonding preferentially occurs between the best donors and best acceptors in the organic solid state. Knowledge of the relative hydrogen-bond acidity and basicity can, therefore, be used in molecular crystal engineering. A liquid chromatography method has been developed to assess the hydrogen-bond acidity of potential hydrogen-bond donors used in cocrystallizations. Hydrogen-bond donor solutes are chromatographed on a polyvinylpyridine-divinylbenzene column under two different sets of mobile phase conditions. The relative retention is proportional to the hydrogen-bond acidity of the solute and therefore, provides an a priori measure of the hydrogen-bond acidity of a potential cocrystal component.

Subject Categories:

  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE