Thallium Toxicity: The Problem; An Analytical Approach; An Antidotal Study
ARMY STUDENT DETACHMENT FORT BENJAMIN HARRISON IN
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Thallium T1 is a highly toxic metal that is anthropogenically concentrated in the environment. Tl toxicity and the quantitative analysis of trace levels of Tl in biologic materials by atomic absorption spectroscopy is reviewed a study designed to evaluate the antidotal efficacy of 2 compounds in the treatment of acute Tl toxicity in rats is documented. Unithiol 2,3- dimercapto-1-propanesulfonic acid, DMPS and prussian blue potassium ferric hexacyanoferrateII, PB, given alone and in combination, were evaluated as antidotes in the treatment of acute thallotoxicosis in male Sprauge-Dawley rats. The relative accumulation of Tl in organs was kidneyheartliver-brain. PB induced significant decorporation of Tl from all tissues. DMPS failed to significantly decrease the Tl content in any organ, but significantly decreased the Tl content in whole blood. PBDMPS treatment significantly decreased the Tl content in all organs, but to no greater extent than PB alone. PB and PBDMPS treatments significantly increased the Tl content of feces, whereas DMPS treatment alone produced little effect. This study indicates that PB is a beneficial antidote in the treatment of acute thallotoxicosis in rats. The failure of DMPS to significantly decrease the Tl content in 4 target organs suggests it would not be useful in the treatment of Tl poisoning....Thallium, Poison, Antidote, Chelator, Prussian blue, Potassium ferric hexacyanoferrateII , Unithiol, 2,3-dimercapto-1-propanesulfonic acid, Rat.
- Inorganic Chemistry
- Organic Chemistry