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Effects of Repeated Administration of Corticotropin-Releasing Factor on Schedule-Controlled Behavior in Rats

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Journal article

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To examine the effects of repeated administration of corticotropin- releasing factor CRF on behavior, rats were administrated ICV injections of either CRF or saline on alternate days for 10 days prior to performing on a multiple fixed-interval FI 60 sfixed-ratio FR 20 schedule for food reinforcement. A daily session consisted of 10 components of each schedule that alternated, starting with the FI component. CRF doses were individually determined for each rat and were either 1.0, 3.0, or 10 micro-g CRF based upon the dose that occasioned more than a 50 reduction in the rate of responding. Acute administration of CRF decreased the rate of responding in both components well below control rates this decrease in responding was associated with a 20 or 50 decrease in the number of earned reinforcements in the FI and FR components, respectively. With repeated administration, CRF-induced suppression of responding was attenuated, although CRF continued to decrease response rate. Despite the continued reduction in response rate, subsequent CRF injections did not result in a loss of reinforcements in the FI component, whereas rats continued to lose 20 of the reinforcers in the FR component. After an 18-day hiatus in which no CRF was administered, the baseline rate of responding on the multiple schedule increased, in particular in the FI component. When CRF was readministered, response rates were slightly suppressed relative to a reestablished saline control but significantly higher than CRF-induced suppression on the last of the chronic regimen. These data demonstrate that with repeated administration tolerance develops to CRF-induced suppression of responding in rats.

Subject Categories:

  • Psychology
  • Medicine and Medical Research
  • Pharmacology

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