Emesis in Ferrets Following Exposure to Different Types of Radiation: A Dose-Response Study
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Ferrets were exposed to gamma rays 60Co, fission neutrons, high-energy electrons 18.5 MeV or iron particles 56Fe, 600 MeVamu in order to establish the dose-response relationships for emesis following exposure to different types of radiation. The results showed that the mean effective doses ED50s for iron particles 35 cGy and neutrons 40 cGy were similar. High-energy electrons were the least effective radiation, with an ED50 of 138 cGy. Gamma rays, with an ED50 of 95 cGy, showed an intermediate effectiveness. The results suggest that the relative effectiveness of different types of radiation generally increases with an increase in linear energy transfer LET, although LET is not completely predictive of relative behavioral effectiveness.
- Medicine and Medical Research