Accession Number:
ADA257407
Title:
Is All Radiation-Induced Emesis Ameliorated by 5-HT3 Receptor Antagonists
Descriptive Note:
Corporate Author:
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s):
Report Date:
1992-01-01
Pagination or Media Count:
11.0
Abstract:
Exposing ferrets to gamma rays or X-rays produces vomiting that can be attenuated by 5-HT3 receptor antagonists and by subdiaphragmatic vagotomy. The present experiments evaluated the effectiveness of these treatments on emesis evoked by exposure to other types of radiation, fast neutrons from a nuclear reactor and high-energy protons 200 MeV, which differ in the relative effectiveness with which they produce vomiting. The results indicated that higher doses of 5-HT3 receptor antagonists Eusatron 0.03 and 0.30 mgkg, s.c. and Ondansetron 0.10 and 0.30 mgkg, s.c. prevented emesis following neutron irradiation. Lower doses of these 5-HT3 receptor antagonists and subdiaphragmatic vagotomy attenuated neutron-induced emesis, increasing the latency and decreasing the severity of the emetic episodes. Ondansetron 0.50 and 1.00 mgkg, s.c. completely prevented vomiting following exposure to high- energy protons. The results are interpreted as indicating that similar 5-HT3- dependent mechanisms mediate emesis produced by exposure to different types of radiation, despite differences in their relative effectiveness.
Descriptors:
Subject Categories:
- Medicine and Medical Research
- Radiobiology
- Pharmacology