Accession Number:

ADA257407

Title:

Is All Radiation-Induced Emesis Ameliorated by 5-HT3 Receptor Antagonists

Descriptive Note:

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

Report Date:

1992-01-01

Pagination or Media Count:

11.0

Abstract:

Exposing ferrets to gamma rays or X-rays produces vomiting that can be attenuated by 5-HT3 receptor antagonists and by subdiaphragmatic vagotomy. The present experiments evaluated the effectiveness of these treatments on emesis evoked by exposure to other types of radiation, fast neutrons from a nuclear reactor and high-energy protons 200 MeV, which differ in the relative effectiveness with which they produce vomiting. The results indicated that higher doses of 5-HT3 receptor antagonists Eusatron 0.03 and 0.30 mgkg, s.c. and Ondansetron 0.10 and 0.30 mgkg, s.c. prevented emesis following neutron irradiation. Lower doses of these 5-HT3 receptor antagonists and subdiaphragmatic vagotomy attenuated neutron-induced emesis, increasing the latency and decreasing the severity of the emetic episodes. Ondansetron 0.50 and 1.00 mgkg, s.c. completely prevented vomiting following exposure to high- energy protons. The results are interpreted as indicating that similar 5-HT3- dependent mechanisms mediate emesis produced by exposure to different types of radiation, despite differences in their relative effectiveness.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE