Accession Number:

ADA256601

Title:

Pemoline and Methylphenidate: Interaction With Mood, Sleepiness, and Cognitive Performance During 64 Hours of Sleep Deprivation

Descriptive Note:

Interim rept. Oct 1988-Sep 1990

Corporate Author:

NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA

Report Date:

1992-07-07

Pagination or Media Count:

39.0

Abstract:

Moderate doses of methylphenidate or pemoline were tested for maintaining cognitive performance during sleep deprivation. Reductions in performance speed and accuracy were a function of both amount of prior wakefulness and hour of day, with greatest decrements between 0000 and 0600, especially the 2d night of sleep loss. At the doses used, pemoline was more effective than methylphenidate in countering the effects of sleep loss and the circadian cycle. Pemoline reduced subjective and objective sleepiness and improved performance speed on most tasks. Effects on accuracy were more variable. Sleep Deprivation, Cognitive Performance, Stimulants, Pemoline, Methylphenidate, Circadian Rhythms.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE