Pemoline and Methylphenidate: Interaction With Mood, Sleepiness, and Cognitive Performance During 64 Hours of Sleep Deprivation
Interim rept. Oct 1988-Sep 1990
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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Moderate doses of methylphenidate or pemoline were tested for maintaining cognitive performance during sleep deprivation. Reductions in performance speed and accuracy were a function of both amount of prior wakefulness and hour of day, with greatest decrements between 0000 and 0600, especially the 2d night of sleep loss. At the doses used, pemoline was more effective than methylphenidate in countering the effects of sleep loss and the circadian cycle. Pemoline reduced subjective and objective sleepiness and improved performance speed on most tasks. Effects on accuracy were more variable. Sleep Deprivation, Cognitive Performance, Stimulants, Pemoline, Methylphenidate, Circadian Rhythms.
- Medicine and Medical Research
- Stress Physiology