Purity Analysis of MNG and Chemical Analysis of MNG and MNNG in Biological Samples.
Final rept. May-Nov 1991,
MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
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Currently N-methyl-N-nitroguanidine MNG is being considered by the Air Force Armament Laboratory for use in explosive formulations. The Toxic Hazards Research Unit THRU has been asked to develop a mammalian toxicity profile of MNG that includes the analysis of chemical impurities, and an assessment of the potential for the metabolism of MNG to 1-methyl-3-nitro-l- nitrosoguanidine MNNG. Potential in situ gastric conversion of MNG to MNNG is a toxicological concern because MNNG is both mutagenic and carcinogenic. N- methyl-N-nitroguanidine was analyzed by high performance liquid chromatography and small amounts of guanidine, methylguanidine, and nitroguanidine were detected. The conversion of MNG to MNNG was investigated by dosing Fischer 344 rats orally with MNG. Gastric contents, feces, and urine were analyzed from these animals. No evidence of conversion of MNG to MNNG was detected in any of the samples analyzed. MNG, N-methyl-N-nitroguanidine MNNG, 1-methyl-3-nitro-1- nitrosoguanidine Metabolism of MNG gastric conversion of MNG to MNNG HPLC analysis of MNG, MNNG, and other guanidines
- Medicine and Medical Research
- Organic Chemistry