Dermal Absorption and Target Organ Toxicity of H-19457C Hydraulic Fluid
Final rept. Aug 1990-Apr 1991
MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
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Phosphate ester-based hydraulic fluids described by Military Specification H-19457 are being used in Navy hydraulic systems. Acute toxicity tests using this hydraulic fluid indicated little toxicity. Repeated inhalation exposures to several species of animals resulted in hepatotoxicity in rats only. Gavage studies with this fluid resulted in endocrine and reproductive effects after repeated doses of less than 2.0 gkg. Because exposure to hydraulic fluids in the Naval environment often is by dermal contact, this study was designed to determine whether target organ effects found after oral administration could be reproduced by dermal administration of the hydraulic fluid. The initial phase of the study determined the bioavailability of the hydraulic fluid following single oral and dermal treatment. The hydraulic fluid was rapidly absorbed following either route of administration. Repeat dermal administration of the hydraulic fluid determined the ovary, adrenal, kidney, and liver as target organs. Serum estradiol levels were increased, however, estrous cycles were unaffected. Dermal, Estradiol, Estrous cycle, Fyrquel 220, Hepatotoxicity, Hydraulic fluid, MIL-H-19457C, Oral.
- Lubricants and Hydraulic Fluids