Evaluation of N-Methyl-n'-Nitroguanidine in Short-Term Genetic Toxicity Tests.
Final rept. 11 Jun-12 Nov 1991,
MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
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N-Methyl-N-nitroguanidine MNG is being considered as a component of Air Force explosive formulations. This chemical was evaluated in several bioassays to assess its potential genotoxic activity. The assays conducted were the Ames Salmonellamicrosomal assay, the Chinese hamster ovaryhypoxanthine- guanine phosphoribosyltransferase forward mutation assay, and the mouse in vivo bone marrow micronucleus assay. Both in vitro assays were conducted in the presence and absence of S9 metabolic activation enzymes. The results of the three genetic tests indicated that MNG does not interact with genetic material. Also, no toxicity was observed for very high dose levels. These assays would therefore predict essentially no genotoxic risk from exposure to MNG. Ames Assay, Forward Mutation Assay, Genotoxicity, N-Methyl-N-Nitroguanidine, Mouse Micronucleus Assay.
- Medicine and Medical Research