Pharmacokinetic Modeling of Trivalent and Hexavalent Chromium Based on Ingestion and Inhalation of Soluble Chromium Compounds.
Final rept. Jun 1990-Dec 1991,
CINCINNATI UNIV OH DEPT OF ENVIRONMENTAL HEALTH
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A physiologically-based model of chromium disposition in the rat has been developed. Absorption, distribution, and excretion of chromium are superimposed on a general physiological model of rat growth and development. The model considers both Cr VI and Cr III, administered either orally or by inhalation. It incorporates reduction of Cr VI to Cr III in all tissues including the lung and the GI tract. Chromium is cleared from the lung by systemic absorption and by mucociliary clearance into the GI tract. Parameter values are based on literature data and on the results of a concurrent experimental study in which rats were given either Cr 111 or Cr VI either in the drinking water or by inhalation. Blood, tissue, urine, and fecal chromium levels were monitored on days 2, 5, 10, 20, and 40 of the 40-day exposure period, and at 20 days postexposure. CrVI, CrIII, Oral exposure, Inhalation exposure, Physiologically-based model.
- Physical Chemistry