Cytotoxicity of Selected Cesium and Zinc Oxythiomolybdates In Vitro.
Final rept. Jun 1991-Jan 1992,
ARMSTRONG LAB WRIGHT-PATTERSON AFB OH
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The toxicity of complex oxythiomolybdate OTM compounds, solid lubricants under development by the Air Force, was determined. The OTMs investigated were unburned and burned 650 deg C cesium oxytrithiomolybdate COTM, zinc oxydithiomolybdate ZODM and zinc oxytrithiomolybdate ZOTM, respectively. An in vitro approach was employed using the rat liver cell line WB 344. Lactate dehydrogenase enzyme leakage LDH, cellular esterase enzyme activity and DNA synthesis analysis were measured to rank-order the toxicity of the test compounds. The ZODM compounds at equimolar concentrations unburned and burned were the only ones found not to produce any effects on WB 344 cells. While unburned COTM and ZOTM compounds were found to exhibit some cytotoxic effects and depress cellular DNA, the cytotoxic effects and DNA depression were more severe with COTM exposures. The burning of the ZOTM compound did not alter its effects on the WB 344 cells. However, burning of the COTM compound was found to reduce its cytotoxic and DNA effects when compared to the unburned COTM exposures. Based on these results, the relative rank-order of toxicity of the three OTMs tested unburned and burned was COTM ZOTM ZODM. Cesium oxytrithiomolybdate, RAT liver cell line WP 344, Zinc oxytrithiomolbdate.
- Anatomy and Physiology