Accession Number:

ADA255818

Title:

Cholinergic Neurotransmission in the Mammalian Retina.

Descriptive Note:

Annual summary rept. 30 Sep 1985-31 Dec 1987,

Corporate Author:

WAYNE STATE UNIV DETROIT MI

Personal Author(s):

Report Date:

1988-01-30

Pagination or Media Count:

35.0

Abstract:

The cholinergic cells in the retina consist of matching subpopulations of amacrine and displaced amacrine cells which ramify narrowly in the inner plexiform layer IPL. Previous cytochemical studies revealed that the hydrolytic enzyme acetylcholinesterase AChE, which terminates the action of acetylcholine ACh, is more widespread in its distribution than the enzyme choline acetyltransferase ChAT, which is responsible for ACh synthesis. Cytochemical techniques were utilized to further define the sites of cholinergic interaction in the retina. Autoradiographic studies showed that both the muscarinic receptor ligand 3Hpropylbenzilyl choline mustard and the putative nicotinic receptor ligand 3Halpha-bungarotoxin bind preferentially in the IPL. RAV Lab animals morphology retina neurotransmitters acetylcholine organophosphates chemical defense.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE