A Comparative Study Regarding the Association of Alpha-2u Globulin with the with the Nephrotoxic Mechanism of Certain Petroleum-Based Air Force Fuels.
Annual Technical rept. 1 Jul 1991-30 Jun 1992,
ILLINOIS UNIV AT URBANA DEPT OF VETERINARY BIOSCIENCES
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Adult male rats have a strain, dose, and time-dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. We are using rat strain variation Fisher 344 and NCI Black Reiter and different hydrocarbon compounds JP-4, JP-8, decalin and trimethylpentane to investigate the hydrocarbon-induced nephrotoxic response. Histochemical and morphometric evaluation of NCI-Black Reiter rats exposed to JP-8 indicate that this strain undergoes an intermediate form of the hydrocarbon-induced nephrotoxicity when compared to the albino Fisher 344 strain. The intermediate nephrotoxic response of the NCI-Black Reiter rat is characterized by approximately a two-fold increase in the number of acid phosphatase reactive lysosomes in renal tubular cells. The NBR rats did not demonstrate an increase in the size of the individual hlysosomes, however, a characteristic lysosomal aggregation pattern occurred in renal tubular cells following hydrocarbon exposure.