Host Factors Contributing to Disability Following Sulfur Mustard Exposure
Midterm rept. 30 Mar 1990-29 Mar 1992
JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF HYGIENE AND PUBLIC HEALTH
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Cytokines are autocrine and paracrine protein hormones produced by cells in response to specific and nonspecific stimuli. They play a major role in both acute and chronic inflammatory processes, including those produced by sulfur mustard SM. Understanding of the role of cytokines in SM lesions should lead to better therapy because various cytokine activators and inhibitors are becoming available. In situ hybridization of the mRNA of various cytokines with radiolabeled antisense RNA probes enables us to visualize under the microscope which cells in tissue sections of SM lesions are producing which type of cytokine. This technique, therefore, demonstrates cell function histologically, even though the cells are no longer alive at the time of analysis.
- Chemical, Biological and Radiological Warfare