The 3D Structure of Some Diarrheal Causing Bacterial Toxins
Final rept. 1 Jul 1987-30 Jun 1992, Annual rept.
VETERANS ADMINISTRATION MEDICAL CENTER PITTSBURGH PA
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The major objective of this research project, to determine the 3D crystal structure of the staphyloccal enterotoxin Beta SEB, was attained. The structure was solved to a resolution of 2.5 A, and the final result has been submitted for publication to the scientific journal, Nature. The T cell receptor binding site was identified and was demonstrated in a sterically detailed manner with the aid of knowledge obtained independently in a mutational analysis. Regions implicated in the binding of SEB to MHC class II molecules also were elucidated in steric detail. All of the SEs A to E inclusive are predicted to s the SEB main chain fold. Staphylococcal enterotoxins 3D structures X-ray diffraction Protein crystallography Superantigen RA 4.
- Medicine and Medical Research