Accession Number:

ADA255257

Title:

The 3D Structure of Some Diarrheal Causing Bacterial Toxins

Descriptive Note:

Final rept. 1 Jul 1987-30 Jun 1992, Annual rept.

Corporate Author:

VETERANS ADMINISTRATION MEDICAL CENTER PITTSBURGH PA

Personal Author(s):

Report Date:

1992-07-23

Pagination or Media Count:

18.0

Abstract:

The major objective of this research project, to determine the 3D crystal structure of the staphyloccal enterotoxin Beta SEB, was attained. The structure was solved to a resolution of 2.5 A, and the final result has been submitted for publication to the scientific journal, Nature. The T cell receptor binding site was identified and was demonstrated in a sterically detailed manner with the aid of knowledge obtained independently in a mutational analysis. Regions implicated in the binding of SEB to MHC class II molecules also were elucidated in steric detail. All of the SEs A to E inclusive are predicted to s the SEB main chain fold. Staphylococcal enterotoxins 3D structures X-ray diffraction Protein crystallography Superantigen RA 4.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE