Accession Number:

ADA254796

Title:

Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality

Descriptive Note:

Rept. for 1 Feb-31 May 1992,

Corporate Author:

EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC

Personal Author(s):

Report Date:

1992-06-04

Pagination or Media Count:

5.0

Abstract:

Studies were begun on a pig made thrombocytopenic by whole body irradiation. The purpose of this study is to evaluate the performance of rehydrated platelets in the absence of normal fresh platelets. The evaluation of tissues and blood samples taken from this animal are still underway. An 81 pound female pig was transported to North Carolina State College of Veterinary Medicine where it received a whole body irradiation dose of 8 Grays. The pig was returned to The Francis Owen Blood Research Laboratory where a CBC was done daily to follow the hematologic changes. Hematocrit, platelet count, hemoglobin and white cell population remained within normal range for five days. On day 5, the platelet count dropped to 86,000cmm and on day 6, it was 11,000cmm. The pig developed an elevated temperature. By day 7, the ear bleeding time BT was greater than 15 min. The pig suffered a wound to the hoof which required cauterization to stop bleeding. Rehydrated platelets were infused to a level of 55,000cmm and a bleeding time was taken.

Subject Categories:

  • Animal Husbandry and Veterinary Medicine
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE