Development of Rules for Folding of Biotechnology Produced Protein.
Final rept. 1 Feb-31 Jul 92,
BIOELASTICS RESEARCH LTD BIRMINGHAM AL
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Two fundamental contributions have been made in Phase I. The target of a Glu pKa shift of up to 3 pH units was exceeded and a series of solutes within the new Tt paradigm can be readily defined as to whether and with what efficacy they enhance or disrupt hydrophobic folding and assembly in proteins.
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