Longterm Follow-Up of Patients in CSP 298 'Treatment of Patients with Acquired Deficiency Syndrome (AIDS) and AIDS Related Complex'.
Annual rept. 1 Apr 91-30 Mar 92,
VETERANS ADMINISTRATION MEDICAL CENTER NEW YORK
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In order to determine whether there is a long-term benefit to initial versus delayed treatment with AZT, a long-term follow-up study is being conducted for patients enrolled in a USAMRDC funded, randomized trial of early versus later zidovudine AZT therapy in patients with symptomatic HIV infection and CD4 counts between 200 and 500 cellscmm. At the present time, the study demonstrates no survival benefits, no reduction in the number or rate of progression to AIDS, no improvements in the quality of life in one or the other treatment arm, and some emergence of low level resistance in patients treated with AZT for more than one year. These studies are continuing with approximately 73 of the original study population. RA 1 A2T Drug Trials HIV Veterans Follow-up.
- Medicine and Medical Research