Accession Number:

ADA254092

Title:

The Effects of Hydrazines of Neuronal Excitability.

Descriptive Note:

Final rept. 1 May 1987-31 Dec 1991,

Corporate Author:

MEDICAL COLL OF VIRGINIA RICHMOND DEPT OF NEUROLOGY

Personal Author(s):

Report Date:

1991-12-31

Pagination or Media Count:

29.0

Abstract:

The hippocampal slice preparation has been used to demonstrate that hydrazines cause seizures. Electrophysiological, biophysical and pharmacological techniques were used to examine the effects of hydrazines at both a single neuron and a systems level in mammalian hippocampus. The investigators have demonstrated that hydrazines increase neuronal excitability and the rate of neuronal firing, but the mechanisms by which they produce these effects remains to be elucidated.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE