Accession Number:

ADA254091

Title:

Development of Methods for Detection of Lipid Peroxidation Products in Human Tissues Generated by Environmental Toxins.

Descriptive Note:

Annual rept. 1 Jul 91-30 Jun 92,

Corporate Author:

MONTANA STATE UNIV BOZEMAN DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1992-06-30

Pagination or Media Count:

4.0

Abstract:

Research to date has resulted in the synthesis of isotope labelled 9- oxononanoate and the development of generic methods for the introduction of a variety of isotopic labels in the 4-hydroxyalkenals. Additional studies demonstrated that 4-hydroxyalkenals could be released from protein sulfhydryl groups. Future studies will investigate whether 4-hyroxynonenal binds to the sulfhydral groups on human rhodopsin interfering with the visual transduction process.

Subject Categories:

  • Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE