Development of Methods for Detection of Lipid Peroxidation Products in Human Tissues Generated by Environmental Toxins.
Annual rept. 1 Jul 91-30 Jun 92,
MONTANA STATE UNIV BOZEMAN DEPT OF CHEMISTRY
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Research to date has resulted in the synthesis of isotope labelled 9- oxononanoate and the development of generic methods for the introduction of a variety of isotopic labels in the 4-hydroxyalkenals. Additional studies demonstrated that 4-hydroxyalkenals could be released from protein sulfhydryl groups. Future studies will investigate whether 4-hyroxynonenal binds to the sulfhydral groups on human rhodopsin interfering with the visual transduction process.