Accession Number:

ADA252339

Title:

Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds.

Descriptive Note:

Final rept. 20 Sep-31 Dec 91,

Corporate Author:

PHARMAKON RESEARCH INTERNATIONAL INC WAVERLY PA

Report Date:

1992-01-31

Pagination or Media Count:

36.0

Abstract:

Bis 2,2-dinitropropyl acetalformal -5050 mixture diphenyl amine stabilizer BDNPAF-DPA were tested for oral toxicity. Groups of ten rats per dose level were fasted and administered the test article orally by gavage. Animals were observed for clinical signs and mortality at 1 and 4 hours after dosing and once daily for 14 days. Based upon the results of these assays, the definitive acute oral LD50 combined sexes for BDNPAFDPA was determined to be 4791.1 mgkg with 95 confidence limits of 3057.7 to 7507.2 mgkg. The definitive acute oral LD50 for BDNPAF-DPA was determined to be 3718.3 mgkg with 95 confidence limits of 3311.2 to 4175.3 mgkg. Oral toxicity, unicharge, propellants, bis-2,2-dinitropropyl acetal, bis-2,2-dinitropropyl formal, lab animals, RA III.

Subject Categories:

  • Anatomy and Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE