Accession Number:

ADA252109

Title:

Limited Toxicity and Mutagenicity Testing of Five Unicharge Propellant Compounds.

Descriptive Note:

Final rept. 20 Sep-31 Dec 91,

Corporate Author:

PHARMAKON RESEARCH INTERNATIONAL INC WAVERLY PA

Report Date:

1992-01-31

Pagination or Media Count:

22.0

Abstract:

N-methyl-, n-ethyl- and n--butyl-2nitratoethyl nitramine MENENA, EtNENA and BuNENA and bis 2,2-dinitropropyl acetalformal -5050 mixture - diphenyl amine stabilizer BDNPAF-DPA were tested for dermal toxicity. One group of ten rabbits per study received the test article once by topical application and was held in contact with the skin for 24 hours. Animals were observed for clinical signs and mortality daily for 14 days. One animal receiving BDNPAF-DPA died during the study. No mortality was observed in any other treatment groups. Based upon the results of these assays, the estimated acute dermal LD50 for MeNENA, EtNENA, BuNENA and BDNPAF-DPA, was determined to be greater than 2000 mgkg.

Subject Categories:

  • Anatomy and Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE