Tumorigenic Evaluation of Jet Fuels JP-TS and JP-7.
Final rept. Mar 91-Feb 91,
MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
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Fischer 344 rats and C57BL6 mice were exposed for one year to inhalation concentrations of either 200 or 1000 mg JP-TSm3 or 150 or 750 mg JP- 7m3. A common control group of rats and mice exposed to air alone was maintained under similar exposure conditions. Six animals of each species, sex, and group were sacrificed at the termination of the one year exposure period. All survivors were maintained for an additional one-year observation period. Significant microscopic findings following the one-year inhalation study were primarily restricted to renal lesions found in male rats. The renal lesions were consistent with changes reported following other hydrocarbon inhalation exposures. Renal neoplasms were slightly increased in number in male rats following the postexposure observation period. No exposure-related degenerative changes or increased carcinogenesis was noted in mice. Fuels, Inhalation, JP-TS, JP-7, Mice, Nephropathy, Rats, Toxicity.