Accession Number:

ADA250872

Title:

Synthetic Vaccines for the Control of Arenavirus Infections.

Descriptive Note:

Annual rept. 1 Aug 90-31 Jul 91,

Corporate Author:

SCRIPPS CLINIC AND RESEARCH FOUNDATION LA JOLLA CA

Personal Author(s):

Report Date:

1991-10-22

Pagination or Media Count:

34.0

Abstract:

During the contract year August 1, 1990 through July 31, 1991, we made substantial progress in several important aspects of our goal to define a strategy to employ synthetic vaccine strategies to immunization against arenavirus infections 1 Refinements of our model of the arenavirus spike structure to include the GP-lGP-2 interaction and the predicted conformation of GP-2 and its interaction an on with the membrane and viral nucleocapsid core. 2 To define the ionic bonding interaction between GP-1 and GP-2 that stabilizes the tetrameric spike. 3 Refinement and extension of the antibody- mediated protection demonstrated against acute LCMV infection. Mice Lab animals RAI BD Arenavirus Glycoprotein Peptide Vaccine Biotechnology C DNA Lassa Plasmids.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE