Control of Circadian Behavior by Transplanted Suprachiasmatic Nuclei.
Annual rept. 15 Nov 90-15 Aug 91,
VIRGINIA UNIV CHARLOTTESVILLE DEPT OF BIOLOGY
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A genetic mutation has been found that alters the free running period of the locomotor activity rhythm from the wild-type value of 24 hours to 20 hours in homozygous mutants. our data suggest the existence of two qualitatively different rhythmic outputs from the circadian oscillators contained with the SCN. One of these outputs stimulates the expression of locomotor activity producing activity rhythms which are seen within , and the other suppresses the expression of activity, restricting its appearance to a temporally defined window and thereby defining the boundaries of p. The idea that one function of a circadian output from the SCN is to suppress activity is novel.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology