Phosphoprotein Regulation of Behavioral Reactivity
Annual technical rept. 1 Mar 1991-29 Feb 1992,
NORTHWESTERN UNIV EVANSTON IL COLL OF ARTS AND SCIENCES
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The effects of protein kinase C activators and inhibitors on two behavioral models that probe memory functions have been studied imprinting in the one day old chick and radial arm maze performance in the adult albino rat. The main conclusion to be drawn is that PKC is necessary but not sufficient for the enhanced durability of memory. In combination with a neural signal, however, PKC demonstrates a profound synergism. This signal can be modulated by a glial-derived factors, S-100. Our most recent behavioral studies have involved the effects of novelty stress and food deprivation stress on yet another role of PKC regulation of transcription factor function. These studies and the initial results suggest that stress can impact on gene regulation.