Investigation of the Hepatotoxic and Immunotoxic Effects of the Peroxisome Proliferator Perfluorodecanoic Acid.
Annual technical rept. 30 Apr 91-30 Apr 92,
OHIO STATE UNIV COLUMBUS
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These studies examine the immunotoxic effects 8 days and 30 days following an intraperitoneal injection of PFDA. Histologic alterations observed in lymphoid organs at 8 days following PFDA treatment were more severe than those apparent at 30 days following PFDA treatment. Relative thymus weight was decreased at both 8 and 30 days following PFDA treatment, whereas relative spleen weight was decreased only at 8 days following PFDA treatment. Proliferation in response to Con A in preliminary 30 day and in vitro PFDA studies was decreased. IgG2a production, but not IgA or IgM production was decreased at 8 but not 30 days following PFDA treatment. DTH response at 8 and 30 days after PFDA treatment tended to be suppressed, although these data were not statistically significantly different. NK activity was increased at 30 but not 8 days following PFDA treatment and appeared to be anorexia-associated. Preliminary data on IL-2R, and spleen and thymic cell populations have been collected. Initial experiments have begun on the effect of PFDA on induction of hepatic Enoyl CoA hydratase. Perfluorodecanoic acid immunotoxic thymic atrophy lymphoproliferation delayed-type hypersensitivity NK cell activity lymphocyte subsets interleukin 2
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