Accession Number:

ADA248825

Title:

Freeze-Dried Human Red Blood Cells

Descriptive Note:

Research progress rept.

Corporate Author:

CRYOPHARM PASADENA CA

Personal Author(s):

Report Date:

1992-04-15

Pagination or Media Count:

82.0

Abstract:

This research report focuses on the third clinical study, and summarizes our progress on lyophilized human red blood cells RBC. We present results of the initial in vivo survival study and demonstrate that by using the current lyophilization procedure, human red blood cells can be successfully lyophilized, reconstituted and infused into a healthy donor with 86 post-transfusion survival. This level of in vivo survival of lyophilized RBC is comparable to fresh non-lyophilized human red blood cells. We also present results that show that reconstituted, lyophilized human red blood cells can be stored in standard blood bank preservatives with excellent maintenance of glycolytic intermediates comparable to that of refrigerated blood.

Descriptors:

• *LYOPHILIZATION
• *BLOOD CELLS
• *FREEZE DRYING
• INFUSIONS
• HEART
• LIVER
• SPLEEN

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE