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Comparative Effects of Antihistamines on Aircrew Performance of Simple and Complex Tasks Under Sustained Operations
Interim technical rept. Jul 1989-Jul 1991
KRUG LIFE SCIENCES SAN ANTONIO TX SAN ANTONIO DIV
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Airborne Warning and Control System AWACS Weapons Director WD cognitive and psychomotor skills were evaluated with terfenadine Seldane and diphenhydramine Benadryl using a performance assessment battery PAB. After nondrug Day 1 training, twelve 3 member teams were tested with Placebo on Day 2, then randomly assigned to Seldane 60 mg12h TID, Benadryl 25 mg4h QID, or Placebo groups on Days 3 and 4. An 8-test PAB was given at 1230 and 1330 each testing day. The Seldane and Placebo groups did not differ appreciably from each other on Days 3 or 4, but differed significantly from the Benadryl group. The group showed degraded performance for 7 variables on Day 3 and for 3 variables on Day 4 compared to the Seldane andor Placebo groups. Subjective measures of fatigue and antihistamine symptoms supported the Day 3 Benadryl impairment. Overall results were consistent with previous research demonstrating cognitive and psychomotor task impairment with Benadryl but not with Seldane. Support for awarding medical flying waivers to non-pilot aircrew who are taking Seldane under the supervision of flight surgeons is offered.
APPROVED FOR PUBLIC RELEASE