Accession Number:

ADA248603

Title:

New Therapeutic Modalities for Laser Retinal Injury

Descriptive Note:

Annual rept. 1 Mar 1990-28 Feb 1991

Corporate Author:

ILLINOIS UNIV AT CHICAGO CIRCLE

Personal Author(s):

Report Date:

1991-03-29

Pagination or Media Count:

38.0

Abstract:

Two grades II and III of retinal lesions were evaluated using clinical, histopathologic, and morphometric methods from 3 days up to 20 days after the laser insult. Morphometric parameters varied according to time and the energy of the laser used. Preliminary evaluation of the efficacy of high-dose, and continuous infusion of methylprednisolone was performed using a swivel- tethering system. Clinical study at 3 and 10 days after laser injury suggested a dramatic beneficial effect when the drug was given at 24 hours before injury and continued for 4 days. Preliminary histopathologic observation also suggested a protective effect of the treatment regimen. Morphometric analysis is underway. In addition, two human cases of laser injury to the retina were studied clinically as a basis for clinical application of therapeutic modalities. Laser Retina Injury Treatment Corticosteroids Methylprednisolone RA 3

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE