Accession Number:

ADA248575

Title:

Evaluation of LEH/LR16 Artificial Blood Formulation

Descriptive Note:

Performance rept.

Corporate Author:

OHIO STATE UNIV COLUMBUS COLL OF PHARMACY

Personal Author(s):

Report Date:

1992-03-01

Pagination or Media Count:

5.0

Abstract:

Nine new LR16 analogues have been synthesized in sufficient amounts to allow for their characterization as modulators of the oxygen affinity of liposome-encapsulated hemoglobin. Among the compounds are nitro-substituted, sulfur-substituted, fluoro-substituted, and quaternized or permanently-charged analogues of LR16. These compounds have not been synthesized previously and thus it will be of interest to evaluate their ability to modulate the oxygen binding affinities of hemoglobin.

Subject Categories:

  • Biochemistry
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE