Accession Number:

ADA248467

Title:

Analysis and Synthesis of Adaptive Neural Elements and Assembles

Descriptive Note:

Annual rept. 1 Oct 1990-30 Sep 1991

Corporate Author:

TEXAS UNIV MEDICAL SCHOOL AT HOUSTON DEPT OF NEUROBIOLOGY AND ANATOMY

Personal Author(s):

Report Date:

1992-02-17

Pagination or Media Count:

15.0

Abstract:

Between October 1, 1990 and September 30, 1991, progress was made in six areas. First, voltage-clamp experiments investigated the modulation of the voltage-dependent K current IK,v by serotonin 5-HT. Second, a computer program that is a general-purpose Simulator for Neural Networks and Action Potentials SNNAP was developed. Third, extensions were made to the single-cell model of associative learning by incorporating Hodgkin-Huxley type membrane currents, descriptions of the modulation of membrane currents by 5-HT, and a model of intracellular Ca2 diffusion. Fourth, SNNAP was used to investigate the role of interneurons in determining the intensity and duration of motor neuron responses that mediate the tail-withdrawal reflex. Fifth, experiments characterized the synaptic interactions among the neurons of a central pattern generator CPG that underlies aspects of feeding behavior. Sixth, SNNAP was used to begin simulating the neurons and synaptic connections of the feeding CPG. In addition, work on the model of the bursting neuron R15 was completed.

Subject Categories:

  • Psychology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE