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Physiological Analyses of the Afferents Controlling Brain Neurochemical Systems.

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Annual rept. 1 Jun 90-31 May 91,

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These experiments are directed at the neurochemical systems and neuroanatomical pathways that control the activity of brain serotonergic dorsal raphe nucleus and noradrenergic locus coeruleus neurons. It seeks to answer these questions by studying single unit activity in combination 6th microiontophoresis in the awake cat during exposure to physiologically relevant conditions. Four series of studies are proposed, the first three will examine the neurochemical afferents that control the following types of activity of serotonergic and noradrenergic neurons 1 tonic, as well as state-dependent activity 2 phasic activity evoked by various sensory stimuli and 3 activation in response to environmental and physiological challenges stressors . The fourth series of studies will take results from the first three and seek to establish the nuclear site of origin of these effects by employing electrical stimulation in combination with single unit recording and microiontophoresis. This research program will provide a critical link for understanding the control of these two important neurochemical systems, and will thus help to elucidate, more broadly, their role in processes such as state-dependent changes in physiology and behavior, and arousal and attention. Serotonin, Norepinephrine, Brain, Neurochemical afferents, Single unit activity, Microiontophoresis, Glutamate, GABA, Attention, Arousal, Bioreactivity, Sleep, Behavior.

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  • Biology

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